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咖啡沙龙第二百一十期——Ancient DNA analysis of coprolites reveals the role of gut microbiota in mammal adaptation to environment

發表日期:2019-03-08來源:放大 縮小

 

報告人(Guest):Dr. Yichen Liu(劉逸宸) 

討論主題(Topic):Ancient DNA analysis of coprolites reveals the role of gut microbiota in mammal adaptation to environment

時間(Time):2019.3.15 上午   9:30-10:30

    (2019.3.15 Friday  9:30-10:30am)

地點(Location):北樓702室(Room 702, North Building 

內容簡介:

Gut bacterial communities (microbiota) perform essential functions for their hosts, including nutrient synthesis, dietary toxin degradation, and host immunity development. Several key examples have recently identified additional, yet unique, roles that the gut microbiota can play in mammalian adaption. However, the evidence of gut microbiota in mammalian adaptation to past environments remains limited, especially within extinct animals. The extinct cave goat (Myotragus balearicus), which maintained a toxic diet, was used as a model species to investigate how the gut microbiota aided mammal adaptation in the past. DNA was extracted from eight ancient goat coprolites (faecal remains), and metagenomic shotgun sequencing was preformed by creating both double- and single-stranded DNA libraries. Robust ancient gut microbiota were reconstructed from the coprolites by utilizing stringent controls and a novel model to assess DNA damage of unmapped DNA sequences. I will present results from this study and will discuss the strength of utilizing paleomicrobiology to explore adaptive processes of the past.

報告人信息:

劉逸宸,澳大利亞古DNA研究中心(Australian Centre for Ancient DNA)博士,主要研究微生物組和表觀遺傳組在古代動物適應環境中的作用。動物的微生物組和表觀遺傳組常常能夠迅速地響應環境刺激,並能在短時間內(1代內)影響動物表型及其對環境的適應度。其興趣領域是,探索如何利用古DNA技術從微進化的時間尺度上來研究微生物組和表觀遺傳組對哺乳動物進化的作用。

 

 

                                                      脊椎动物演化与人类起源重点实验室

                                                                                                            2019.3.8

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